Advanced Thermogenic Fat Burner

  • Say "WOW" from the first single pill serve.*
  • Amazing "feel good" vibe.*
  • Helps shed excess water retention.*
  • A potent & long-lasting energy and focus.*
  • The strongest fat burner using mitochondrial uncoupling and lipolytic agents available on the market today.*

Thermadex is PNI’s serious fat-burner, and it has been carefully engineered using the most advanced and potent ingredients possible. 

You will say "WOW" from your very FIRST single-pill serving!

Thermadex is much more than just another “fatloss” clone. PNI have created an entirely new type of fat-burning product, designed to reflect the belief that:

  • A ‘fat-loss’ product should preferentially burn fat, while helping you hold on to your hard-earned muscle.
  • Stimulation is desirable, but over stimulation can be detrimental due to rebound effects & muscle catabolism.
  • For a fat-loss product to be extraordinarily effective, every lipolytic pathway needs to be targeted.


In keeping with principle , Thermadex selectively targets fat cells and destroys them without mercy, using every weapon at science’s disposal: It elevates UCP expression in white adipose tissue, directly hits alpha and beta adrenoreceptors, induces catecholamine release, activates thermogenesis-inducing vanilloid receptors, blocks PPAR-gamma, shifts the body’s preferential energy source from glycogen to free fatty acids, and inhibits cAMP breakdown.* To get into the details of how it manages to do all this, we’ll need to speak about the ingredients.

Higenamine has tremendous benefits when used as a pre workout supplement to help increase energy, improve focus, and enhance mental clarity. Unlike many other stimulants, it does not affect nitric oxide production and it does not constrict or dilate the veins. This can be quite useful for athletes, especially those engaged in weight training and other explosive type of sports since they can continue to see benefits from their nitric oxide supplements at the same time as using Higenamine .

There is also a lot of evidence to suggest that Higenamine acts as a fat burner. This chemical has traditional uses as a bronchodialtor and has a molecular structure and fat burning mechanism very similar to Ephedrine. Higenamine works by stimulating the activity of specific enzymes that boost the fat-burning effects and activity of chemical messengers involved in the metabolic process of burning adipose (fat) tissue. All of this suggests that Higenamine could be one of the best fat burning supplements available today .

Raspberry Ketones
Researchers found that supplementing with Raspberry ketones, may support hormone sensitive lipase (HSL), in the vesicles that fat cells use to store their fatty acids.* Raspberry ketones may help promote fat cells to mobilize and excrete their fatty acids, supporting healthy body composition.*

Bitter Orange Extract
Bitter Orange Extract contains phenethylamine alkaloids such as hordenine, synephrine, octopamine, methylsynephrine, tyramine, and N-methyl-tyramine. These compounds can release norepinephrine (ref), inhibit its reuptake (ref), activate alpha/beta receptors (ref,ref), and activate TAAR1 (ref). These amines don’t need much introduction, as they’re in just about every commercial ‘fat-loss’ product out there. None of them can hold a candle to their ancestor ephedrine, and they fall a little bit short as standalone fat-loss agents… but they can impart mental focus, energy, and even mild euphoria. For reasons of alpha/beta adrenoceptor stimulation, they also work extremely well with the other lipolytic and thermogenic ingredients in Thermodex. We use only the highest quality bitter orange extracts, standardized to 90% phenethylamine alkaolids.

Caffeine Citrate
Caffeine Citrate which has been shown to cross the blood brain barrier faster giving it faster onset and more initial punch and also will be using a higher standardized Citrus Aurantium which yields more of the active alkaloids.

Theobroma Cacoa Extract (Standardized for Theophyline)
Theophyline. This naturally occurring ingredient is found in Green Tea. Theophyline acts on cells by increase the cAMP or intracellular cyclic adenosine monophosphate. cAMP helps the cells make use of glucagon and adrenaline. If you want to increase a fat burning hormone in your body then focus on glucagon. It’s the hormone that tells the adipose tissues to release their fat stores! Usually, glucagon is released when you are going through periods of starvation or stress. Now you don’t need to be placed in stressful conditions just to get energy from your adipose tissues.

Thermadex Black Supplement Facts
As a Dietary supplement take 1 capsule on an empty stomach once or twice per day, Take at least 6 to 8 hours apart. to access tolerance, start with taking only 1 capsule per day.

PNI Thermadex Black review by cz0
  • Overall
  • Flavour
  • Formula
  • Effectiveness

Of the 4 days I used this, I didn't experience anything really out of the ordinary. I expected big things from the Caffeine Citrate, but alas, I didn't notice any real difference.

The unfortunate downside here is that I was looking forward to using this as a morning kick-ass-outta-bed supplement, especially being a cap which makes it easier upon waking than a powder.

On day 1 mood wise I felt slightly above average I guess. But past that, (experimenting, fasted, non fasted, different times of day, always on empty stomach) I really didn't feel a lot. Day 1 could well have just been a placebo.

As far as fat loss is concerned, it contains ingredients you would expect to find in a lot of other products. And without a break down on dosages it's even harder to rate. I gave the formula a higher score due to innovation and trying something new. Unfortunately with my caffeine tolerance, I just don't think it really hit me the way that I was expecting.

PNI Thermadex Black review by vinnie
  • Flavour
  • Formula
  • Effectiveness

As usual I will leave the analysis of the formula to those more informed than I. Taken this 4 days in a row on an empty stomach, have not noticed any obvious thermo effect. What I can comment on is the "feels", I like! Not Detonate levels but for me a really nice energy, great focus, and an hour of being chatty friendly guy if I am out in the big bad world. This, without any of the fuzzy, slightly "meh" feels that I have experienced on other products of a similar nature. Solid product for sure.

PNI Thermadex Black review by The Swole Patrol
  • Overall
  • Flavour
  • Formula
  • Effectiveness

First thing you notice when comparing the ingredient list of both Thermadex, and the new Thermadex Black, is that the proprietary blend has been reduced from 556mg to 480mg.
This might seem as if they've watered it down, but i think the word 'refined' is more fitting.

For me, the new Thermadex outshines the original for a number of reasons.
With the old formula, I would sweat like i'd just done some HIIT. Even if i was just sitting still. With Thermadex Black, i felt significantly hotter inside, but the sweat wasn't spraying out of every pore, which was a nice change.
The old formula gave me incredible focus and energy, but was lacking in the 'feel good' vibe that I get from ANS Diablo. Seems as though they have addressed this as the focus was still there, but the 'feel good' vibe was definitely also their.
Depending on what I had eaten, the old formula would occasionally make me feel a little light headed, (this could be due to the caffeine content being higher, though hard to tell from a proprietary blend) the new formula didn't seem to have that problem.
Keep in mind I do intermittent fasting and usually don't have my first meal until around 2pm, so the fat burner is always taken and used on an empty stomach.
I also quite like the noticeable change in my heart rate, it wasn't uncomfortable, but it was nice to know the product was working and i'm thinking this is due to the higenamine.

Overall I think it's safe to say they have improved the formula, and refined their product.
Can't think of any other product on the market I enjoy using (other than Diablo) more than this new Thermadex Black.


PNI Thermadex Black review by Varis
  • Overall
  • Flavour
  • Formula
  • Effectiveness

Really like these, So much hype around them because I think they're better than the previous Thermadex.. Hence replacing the Old one with the Black Series, It's quite a clean consistent energy.. Using a different form of caffeine which stays in your system for a good feel good vibe, I actually liked the stim so much in Thermadex Black i was opening the capsules and mixing it with a non stimulant pre-workout haah!! Overall I'd say a easy 9/10

PNI Thermadex Black review by donz
  • Overall
  • Flavour
  • Formula
  • Effectiveness

Popped a few of these so far ( 9 infact at various times on various stomachs/situations ) have not been dissapointed! Very strong focus and nice solid stim! Great for getting through those tough cardio patches - fun to drop at work too haha! Solid product!

PNI Thermadex Black review by SuppGuru
  • Overall
  • Flavour
  • Formula
  • Effectiveness

Good to have a new fat burner with new ingredients I can noticeably respond to.

Mood and energy were just right- 2 caps a little too much so a 1 cap product for me. Especially on an empty stomach before breakfast. Took about an hour to kick in but had really nice energy for at least 4-5 hours.

Timing my 2nd serve around 2pm completely blocked sugar cravings

Recommend as a great addition to weight loss with summer around the corner

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5 fortnightly payments of $15.98 or
10 weekly payments of $7.99
6 weeky interest-free payments of $13.33
Sorry, this product has been discontinued

PNI Thermadex Black 60 caps

86% of 100
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